I can’t remember which episode it is, but there’s an episode of one of Anthony Bourdain’s shows where he visits a restaurant run by his friend.

This chef is serving a massive multi-course meal, something like 10+ courses, and knows that Bourdain is a heavy smoker. So at one point he brings out the next course and tells Bourdain something along the lines of “And this one is made with tobacco, so you won’t try and get up in the middle of my dinner and go smoke”.

I guess if the dose is low enough and the tobacco is mixed with the right foods, it could possibly make for an interesting flavour combination.